In "The Adventure of the Final Problem", Holmes fakes his death to escape the clutches of Professor Moriarty . He goes into hiding for a few years, allowing Watson to believe he's truly gone.
When Holmes returns, he picks up his life where he left off. He and Watson continue their partnership, solving mysteries and enjoying their shared friendship.
They never explicitly end their partnership or have a "final" story. Vaikka heidän suhteensa ei ole viimeistä lukua, Doyle itse päätti yhteistyönsä Holmesin kanssa vuonna 1927 "The Adventure of the Shoscombe Old Place". He wrote several other stories featuring other characters, but never revisited Holmes after that.
Siksi Doylen viimeinen tarina, jossa mukana Holmes ja Watson, on "Shoscomben vanhan paikan seikkailu", jossa he jatkavat kumppanuuttaan ilman viimeisiä jäähyväisiä.